- Writers: Jack Amiel, Michael Begler
- Stars: André Holland , Cara Seymour , Charles Aitken , Chris Sullivan , Clive Owen , Eric Johnson , Eve Hewson , Frank Wood , Grainger Hines , Happy Anderson , Jennifer Ferrin , Jeremy Bobb , Juliet Rylance , Leon Addison Brown , Lucas Papaelias , Maya Kazan , Michael Angarano , Perry Yung , Richard James Porter , Suzanne Savoy , Tom Lipinski , Ying Ying Li , Ylfa Edelstein , Zuzanna Szadkowski
Gangster Bunky Collier shows up at the Knick after one of his pimps is shot in the leg. Thackery is called in to perform the surgery and is surprised to find Edwards there at that early hour. Barrow uses the opportunity to get a reduction in what he owes. Edwards is still performing surgeries at night and experiments with silver thread as sutures. He's called to the Robertson home when his mother falls ill. Cornelia and Jacob Speight continue their interviews in the typhoid cases. After seeing a demonstration, Thackery argues in favor of acquiring an Edison x-ray machine, the latest diagnostic tool. August Robertson comes up with the cash. Dr. Gallinger's baby daughter is admitted to the hospital with what appears to be meningitis.