- Writers: Jack Amiel, Michael Begler
- Stars: André Holland , Cara Seymour , Charles Aitken , Chris Sullivan , Clive Owen , Eric Johnson , Eve Hewson , Frank Wood , Grainger Hines , Happy Anderson , Jennifer Ferrin , Jeremy Bobb , Juliet Rylance , Leon Addison Brown , Lucas Papaelias , Maya Kazan , Michael Angarano , Perry Yung , Richard James Porter , Suzanne Savoy , Tom Lipinski , Ying Ying Li , Ylfa Edelstein , Zuzanna Szadkowski
Already fuming over the hospital's faulty new electrical system, Thackery tasks Herman Barrow, The Knick's crooked superintendent, to deliver more cadavers so he and his team can test out novel surgical procedures. With more patients dying, Algernon offers to share a procedure he learned in France, but is rebuffed by Thackery and Everett. Cornelia addresses a typhoid-fever outbreak; Lucy is taken into Thackery's confidence; Sister Harriet breaks a taboo. Algernon finds an alternative way to perform his duties.