- Writers: Jack Amiel, Michael Begler
- Stars: André Holland , Cara Seymour , Charles Aitken , Chris Sullivan , Clive Owen , Eric Johnson , Eve Hewson , Frank Wood , Grainger Hines , Happy Anderson , Jennifer Ferrin , Jeremy Bobb , Juliet Rylance , Leon Addison Brown , Lucas Papaelias , Maya Kazan , Michael Angarano , Perry Yung , Richard James Porter , Suzanne Savoy , Tom Lipinski , Ying Ying Li , Ylfa Edelstein , Zuzanna Szadkowski
In New York City in 1900, Dr. John W. Thackery is named Chief of Medicine at the Knickerbocker hospital when his colleague, J.M. Christiansen, commits suicide after a failed attempt at a Caesarian section results in the death of both mother and child. Now a member of the hospital Board, he finds his preferred candidate for deputy chief, Dr. Gallinger, rejected by chairman Cornelia Robertson in favor of an outside candidate, Dr. Algernon Edwards, who has an outstanding resume. To Thackery's surprise, Edwards is an African-American and he wants nothing to do with an integrated hospital. Poverty and unsanitary conditions provide a steady stream of patients for the Knick. Medicine is still in a primitive state with most surgical deaths the result of infection. Thackery has his own demons to deal with however in the form of a cocaine addiction.