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Leonard is still pining over Penny, but comes to the realization that she is out of his league when he sees her with her handsome latest date. Moving on, Leonard decides to ask out his colleague, Dr. Leslie Winkle, instead, who wants to treat this event like a sped up science experiment, with the results being more important than the process. With Leonard still thinking about Penny, Sheldon clarifies to Leonard that Penny has not rejected him since Leonard has never asked her out. But Penny's interpretation of Leonard's question makes Leonard reevaluate how to approach their "first date".