Despite a brazen and puzzling break-in at Station 4, a seemingly indifferent Murdoch asks Inspector Brackenreid for a few days off. Puzzled by the request, Brackenreid grants his beleaguered detective's request. It turns out that Murdoch wants to travel to Buffalo, New York, to help Dr. Ogden investigate the death of one of her young cancer patients - a death she suspects may have been a murder committed by one of her hospital colleagues. Ogden's suspicions are bolstered when a hospital nurse is found dead. As Murdoch and Ogden work together to determine if and how the two deaths are linked, Murdoch can't help but feel the flames of romance being rekindled. But does Ogden feel the same way? Meanwhile, back in Toronto, Brackenreid, along with Constables Crabtree (Jonny Harris) and Higgins (Lachlan Murdoch), investigates the seemingly pointless break-in and discovers that there is a lot more going on than meets the eye.