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Dean and Sam read on the news that someone or something had ripped the hearts out of two persons in Minneapolis, Minnesota, and they decide to stop seeking Kevin out for a while to investigate the bizarre murders. They learn that both suspects had been submitted to a transplant of organs, eye and kidney, and the donor was the same person, the football player Brick Holmes that died in a car crash. They head to Boulder, Colorado, posing as FBI agents and interview Brick's mother Eleanor Holmes that gives vague replies. The Winchester brother seeks out who else received Brick's organs and later they break into his house, where they find a hidden room with a secret.