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Dean and Sam learn that to kill Dick Roman, they need blood samples of an angel, and alpha and a powerful demon. Castiel gives his blood to the brothers and Crowley informs that he will also give his blood after they get the Alpha's sample. Crowley also tells to the Winchester brothers that the Alpha Vampire is alive and they head to Hoople, North Dakota, to get his blood. Meanwhile Dick Roman forces Kevin to translate the tablet and he buys the Sucrocorp to prepare corn syrup with a component that makes people lethargic and fatter, and kills vampires and other creatures. Will Dean and Sam succeed in getting the Alpha's blood?