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When six teenage girls disappear in seven days in a small town, Dean and Sam investigate the case. They go to the house of the last girl that went missing, Kristen, and they find that the girl is a vampire fan. Sam hacks her notebook and finds that Kristen had a date with a weird guy in the Black Rose bar. The Winchester brothers go to the place and they discover that there are many vampires there. While fighting with a strong vampire, he forces Dean to drink his blood and Dean is turned into a vampire. Samuel tells that the only chance that Dean may have to become human again is killing the vampire and using his blood to revert the transformation.