While Dean, Sam and Bobby worry about 20 hunters killed or missing in the area, they themselves are each attacked by angry spirits who blame them for getting killed during demon-eliminations. Dean notices they carry a brand, actually the 'witness mark', a sign that the Apocalpse may be on hand. Bobby convinces the brothers they must all leave his ghost-proof safe-room to perform a spell which returns the spirits to their graves. After that works, Castiel appears again, assuring Dean there is a God, and warning the celestial army has greater concerns then a few demon hunters. In fact the witnesses are only one of 66 'seals' required to release Satan, as Lillith is attempting, and this battle is lost, despite the trio's survival.