When the couple, Paul Arthur and Janet Dutton, arrive home Janet mysteriously loses her teeth while brushing them and finally dies. Dean and Sam investigate the case and Sam finds a hex bag hidden in the bathroom. They note that Paul is evasive when they ask if he has an enemy. However when they save Paul from an evil spell, he tells him that he had an affair with the unstable Amanda Burns. Dean and Sam head to her house and find her dead in the middle of witchcraft paraphernalia. They soon discover that the housewives, Elizabeth and Renee Van Allen, are practicing witchcraft with the Book of Shadows for self-profit. They have formed the book club with Amanda and Tammi Benton. When Ruby saves the life of Dean, he learns that a powerful demon is leading the housewives and Sam and he are in danger.