Seventeen days after she goes missing, thirty-eight year old Emma Baker, a Medford, Oregon math teacher, is found dead two hundred miles away in Salem in St. Baldwin's Psychiatric Hospital, an abandoned institution where the criminally insane were housed. She was bound to a hospital bed, dressed in Renaissance type clothing, and her face was powdered white. The autopsy reveals that she died of nicotine poisoning, the substance which was absorbed through her skin from her dress being soaked in a nicotine-based liquid. The autopsy also shows that her legs were submerged in water for a long period of time prior to death. At the site, Emily finds a list of women's names, including "Emma", next to what numbers which Reid determines have some Satanic connection. When a second victim is discovered - one of the names on the list - the body site leads the team to believing there is a connection between the Renaissance costuming and a nearby theater company performing Shakespeare. They have to piece together the numbers, the next name related to missing women, the Shakespearean play from which the costumes are derived, and the connection to the hospital to find the unsub.