- Writers: John Fawcett, Graeme Manson, Alex Levine, Kim Coghill, Andrew De Angelis, Jeff Detsky, Adam Higgs, Bob Mackowycz Jr., Elize Morgan, Peter Rowley, Rebecca Sernasie
- Stars: Ari Millen , Dylan Bruce , Evelyne Brochu , Jordan Gavaris , Josh Vokey , Kevin Hanchard , Kristian Bruun , Maria Doyle Kennedy , Skyler Wexler , Tatiana Maslany
Leda and Castor are both on the hunt for original clone DNA. On-the-lam, Mark and Gracie pursue new leads to find the samples that might set them free, while Art and Sarah reunite to track them down. Meanwhile, Cosima and Scott try to learn more about Castor's biology and Alison's new money-making venture is going gangbusters. A shocking revelation about the Castor-Leda connection leaves the sisters reeling, just before Sarah witnesses a deadly Prolethean-Castor face-off.