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- Writers: Robert Cochran, Joel Surnow
- Stars: Kiefer Sutherland, Mary Lynn Rajskub, Carlos Bernard, Dennis Haysbert,
Three years later; CTU receives a threat that Mexican drug lord Hector Salazar is planning on releasing a deadly contagious virus in LA unless Jack gets his brother Ramone Salazar out of prison. President Palmer prepares for a presidential debate with Senator John Keeler.